levomethadyl acetate การใช้

• Levomethadyl acetate is the " levo " isomer of ?-methadyl acetate.
• The drug, called levomethadyl acetate or LAAM, won federal approval in 1993 after years of sitting on the shelf.
• Orlaam, another synthetic narcotic known generically as levomethadyl acetate, was approved in 1993 but has not been widely used.
• Levomethadyl acetate HC is manufactured by Roxane Laboratories Inc . of Columbus, Ohio, and is marketed under the brand name Orlaam.
• Those receiving high-doses of Orlaan, known chemically as levomethadyl acetate hydrochloride, or LAAM, reported using heroin 2.5 days in the past 30.
• Those receiving high-doses of Orlaan, known chemically as levomethadyl acetate hydrochloride, or LAAM, reported using heroin 2 . 5 days in the past 30.
• Levomethadyl acetate undergoes extensive first-pass metabolism to the active demethylated metabolite nor-LAAM, which is further demethylated to a second active metabolite, dinor-LAAM . These metabolites are more potent than the parent drug.
• The isomer L-?-methadol is the active metabolite of the long-acting opioid substitute drug levomethadyl acetate ( LAAM ), and has been used much more widely than ?-methadol or the racemic mixture of dimepheptanol.
• In some countries, other opioid derivatives such as levomethadyl acetate, dihydrocodeine, dihydroetorphine and even heroin are used as substitute drugs for illegal street opiates, with different prescriptions being given depending on the needs of the individual patient.
• The agency said Friday the new warning is the result of 10 cases of serious heartbeat rhythm changes among patients taking levomethadyl acetate HC . The drug is used to treat addiction in patients who have had poor response to other addiction treatments.